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Prednisone - (drugs) substances of natural or synthetic origin or their mixtures, used mainly for the treatment and prevention of diseases (eg, antianginal drugs, antipyretics) ... Big Encyclopedic Dictionary. MEDICINES - MEDICINES, in medicine, any substance used to diagnose, prevent and treat a DISEASE or to restore health after an injury. Medicines have long been (and up to the present time) received from natural sources. Scientific and technical encyclopedic dictionary.